FEIT Research Project Database

Biofabrication and matrix mechanobiology of cartilage tissue models


Project Leader: Kathryn Stok
Student: Manuela Boos
Primary Contact: Kathryn Stok (kathryn.stok@unimelb.edu.au)
Keywords: biofabrication; biomaterials; biomechanics; mechanobiology; tissue engineering
Disciplines: Biomedical Engineering,Mechanical Engineering
Domains:

The aim of the research is to develop a cartilage tissue model in order to investigate tissue and cellular responses to mechanical stimuli in a multiscale manner.

During human movement, mechanical stimuli are passed from the whole body through the joints and tissues to the cell. There is continuous feedback between cartilage cells (chondrocytes) and the mechanical force they receive from the surrounding matrix. This “mechanosensation” signals cells to produce and degrade matrix products, changing the mechanical environment that surrounds them. Many studies and techniques have demonstrated the cell response to mechanical stimulation, but none describe the continual mechano-adaptation feedback of cartilage at the microstructural level over time. By developing novel methods allowing us to study structural remodelling over time we can explore the role of mechanics in this feedback loop.

The specific aims of this PhD project will therefore be to:

  1. Develop cartilage tissue-engineered models for exploration of mechano-adaptation over time
  2. Combine digital volume correlation and tissue quantification to describe tissue remodelling and mechano-adaptation.

Further information: https://biomedical.eng.unimelb.edu.au/integrative-cartilage/student-projects

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