FEIT Research Project Database

Time-lapsed imaging of arthritis progression

Project Leader: Kathryn Stok
Staff: Catherine Davey
Student: Pholpat Durongbhan
Collaborators: Andy Kin On Wong, Mohit Kapoor
Primary Contact: Kathryn Stok (kathryn.stok@unimelb.edu.au)
Keywords: biomechanics; biomedical engineering; imaging; mechanobiology; micro-computed tomography
Disciplines: Biomedical Engineering

The aim of the research is to perform in vivo longitudinal contrast enhanced micro-computed tomography and investigate mechanisms driving remodelling due to arthritis.

Arthritis is a common and painful disease triggering structural and biochemical changes. Nevertheless, factors influencing changes at the interface between cartilage and bone (osteochondral interface) are not yet well understood.

The specific aims of this PhD project will therefore be to:

  1. Develop preclinical imaging techniques for live capture of the osteochondral interface
  2. Assess genetic and biochemical determinants that mediate remodelling in a mouse model
  3. Evaluate cartilage and bone remodelling and compare with biomarkers of disease.

This PhD project forms part of a cluster collaboration between the University of Toronto and the University of Melbourne. Prior to arriving at the University of Melbourne, the student will be enrolled in the Collaborative Program in Musculoskeletal Sciences at the University of Toronto for 18 months. They will be trained in basic sciences of bone, muscle and joint biology, image processing, seminars on other PhD students’ work in similar fields, and have opportunities to collaborate across departments.

Further information: https://toronto.research.unimelb.edu.au/2020/12/15/mechanisms-driving-osteochondral-remodeling-in-a-postmenopausal-animal-model-using-longitudinal-contrast-enhanced-micro-computed-tomography/

Arthritis progression in a mouse