FEIT Research Project Database

Biophysics of cell adhesion: discovering how nanoscale features impact the cell response

Project Leader: Daniel Heath
Staff: Daniel Heath, Andrea O'Connor, Ray Dagastine
Sponsors: ARC
Primary Contact: Daniel Heath (daniel.heath@unimelb.edu.au)
Keywords: biomaterials; biomedical engineering; nanotechnology; tissue engineering
Disciplines: Biomedical Engineering,Chemical & Biomolecular Engineering

Cells interact with nanoscale features in their environment. The nanoscale spacing of cell adhesive ligands is of particular importance, as it is a main driver for the formation of focal adhesions and intracellular signalling. This project aims to understand the biophysics of cell adhesion by determining how the nanospacing of cell adhesive ligands drive cellular processes. This will be accomplished using atomic force microscopy to create well-controlled nanoscale features. Cellular responses to the surfaces will then be assessed through AFM and advanced microscopy techniques.