MSE Research Project Database

Systems biology of heart cells

Project Leader: Edmund Crampin
Primary Contact: Edmund Crampin (
Keywords: biomedical engineering; cardiovascular disease; numerical modelling; systems biology
Disciplines: Biomedical Engineering
Research Centre: Systems Biology Laboratory

Cellular function is determined by the complex network of interacting biological processes occurring within and between cells. Integrative modelling provides a means of assessing the quantitative contribution of each of these components, and assessing potential therapeutic strategies in disease. With a focus on understanding regulatory mechanisms, we are developing biophysically-based models of a range of cellular processes in relation to heart cell function and heart disease.

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