MSE Research Project Database

Calcium signalling in cardiac cell growth


Project Leader: Vijayaraghavan Rajagopal
Staff: Agne Tilunaite, David Ladd
Student: Hilary Hunt
Collaborators: Edmund Crampin (BME, Math and Stats) Eric Hanssen (Bio21 Institute), Llewelyn Roderick (KU Leuven), Christian Soeller (University of Exeter)
Sponsors: Australian Research Council
Primary Contact: Vijay Rajagopal, Edmund Crampin (vijay.rajagopal@unimelb.edu.au)
Keywords: biomechanics; fluid structure interactions; heart; numerical modelling; systems biology
Disciplines: Biomedical Engineering,Chemical & Biomolecular Engineering,Computing and Information Systems
Domains: Convergence of engineering and IT with the life sciences
Research Centre: Systems Biology Laboratory

Our hearts beat roughly 2.2 billion times through the course of our lives. Unlike man-made pumps that have a fixed operating range for pumping fluid, the heart has an amazing capacity to simultaneously modulate the force and rate with which it contracts to meet changes in our body’s demand for blood supply. Short term changes in blood supply demand (eg, sprinting or climbing stairs) are met by increasing the heartrate. Long-term changes (over weeks and months) occur with endurance training, pregnancy and growth into adulthood. An increased heartrate cannot sustain these long-term changes. Instead, the heart adapts to long-term changes by increasing its size through a process called hypertrophy. The heart’s size is governed by the size of each of its constituent cardiac cells and not by the number of cells; cardiac cell growth is governed by the cell nucleus. The goal of this project is to address a fundamental gap in our understanding of what signal in the cell nucleus triggers hypertrophic cell growth. This missing knowledge has implications across cell biology because of the fundamental importance of hypertrophy to biological systems. A fundamental understanding of how hypertrophy is triggered in the cell nucleus has implications for treating many heart related diseases, including high blood pressure or diabetes, where hypertrophy is triggered as an adaptation but often exacerbates the condition and leads to death.

We are seeking to recruit highly motivated PhD students with a Bachelors or Masters degree in Applied Mathematics, Biomedical Engineering, Computer Science or related fields. Students do not need a prior background in biology but must have a strong interest to learn cell biology and to contribute to the field using new mathematical and computational models.